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I have been using pramipexole going on 10 months. I am now able to sleep and get a good night's rest. I have found if I miss a dose then I don't sleep and my legs drive me crazy. Is anyone else noticing the RLS occuring earlier in the day even when on the medicines? My legs start to get jumpy etc as early at 3pm and I do not take my pills till I go to bed at night.

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The B-subtype selective (a drug developed for the treatment of PD) has now been approved for the treatment of depression in the form of a patch ().

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SAD(maybe a genetic problem) and it seems using dopamine agonists and releasers are the only effective ways now.

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